The public transport infrastructure consists of an integrated transport system of Prague Metro, Prague Tram System, buses, the Petřín funicular to Petřín Hill, and five ferries. All services have a common ticketing system, and are run by The Prague Public Transit and some other companies. Recently, Prague integrated transport coordinator has franchised operation of ferries on the Vltava river, which are also a part of the public transport system with common fares.

The city forms the hub of the Czech railway system, with services to all parts of the Czech Republic and abroad. There is also a commuter rail system known as Esko Prague which serves the Prague metropolitan area.

Prague's main international railway station is Hlavní nádraží. Intercity services also stop at the main stations Praha-Smíchov, Praha-Holešovice, Praha-Libeň and Masarykovo nádraží. In addition to these, there are a number of smaller suburban stations. In the future rail should play a greater role in Prague Public Transport System.

Prague is served by Ruzyně International Airport, the biggest airport in the Czech Republic and one of the busiest in Central and Eastern Europe. It is the hub of the flag carrier, Czech Airlines, as well as of the low-cost airline Smart Wings operating throughout Europe.