Cuenca Cathedral was built from 1182 to 1270. The façade was rebuilt after it crumbled down in 1902. It is the first gothic style Cathedral in Spain (together with Avila's one), because of the influence of Alfonso VIII's wife, Eleanor, daughter of the King of England and his wife, Eleanor of Aquitaine, who introduced the Anglo-Norman style.

From that date the cathedral has undergone some changes. An apse-aisle (doble girola) was added in the 15th century, while the Renaissance Esteban Jamete's Arch was erected in the 16th century. The main altar was redesigned during the 18th century by famous architect Ventura Rodríguez: it features a precious iron-work gate. The façade was rebuilt in 1902 from ruins due to the collapse of the former bell tower, the Giraldo. In the early 1990s modern coloured windows were installed, and in 2006 one of the two old baroque organs from Julián de la Orden was recovered. The other organ has also been restored, and on 4 April 2009 an inauguration ceremony was held.

The naves do not follow exactly a straight line. The San Julián altar, dedicated to Saint Julian of Cuenca, at the apse-aisle, consists of columns made of green marble.

Another curiosity are the "Unum ex septem" signs at some chapels. It is said that if one prays looking at these signs one would obtain a five-year forgiveness for one's sins, and seven years if one prays during the patron saint's day.